Prolyl 4-hydroxylase subunit beta (P4HB) could serve as a prognostic and radiosensitivity biomarker for prostate cancer patients.

ABSTRACT:

Background

Prolyl 4-hydroxylase subunit beta (P4HB) has been reported as a suppressor in ferroptosis. However, no known empirical research has focused on exploring relationships between P4HB and prostate cancer (PCa). In this research, we initially examine the function of P4HB in PCa by thorough analysis of numerous databases and proliferation experiment.

Methods

We analyzed the correlations of P4HB expression with prognosis, clinical features, mutation genes, tumor heterogeneity, stemness, tumor immune microenvironment and PCa cells using multiple databases and in vitro experiment with R 3.6.3 software and its suitable packages.

Results

P4HB was significantly upregulated in tumor tissues compared to normal tissues and was closely related to biochemical recurrence-fre

SUBMITTER: Feng D 

PROVIDER: S-EPMC10362756 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature