Long-term changes of Th17 and regulatory T cells in peripheral blood of dogs with spinal cord injury after intervertebral disc herniation.

ABSTRACT:

Background

Intervertebral disc herniation (IVDH) is one of the most common causes of spinal cord injury (SCI) in dogs. As a result of acute SCI, a complex inflammatory response occurs in the spinal cord. Th17 cells (Th17) produce pro-inflammatory cytokines, while regulatory T cells (Treg) have opposite effects producing anti-inflammatory cytokines. Therefore, the aim of this study was to determine whether Th17- and Treg cells are involved in the pathogenesis of SCI or whether cellular changes occur due to coexisting inflammatory diseases. We hypothesized that chronic alterations in the Th17/Treg ratio are associated with a worse outcome after SCI.

Methods

Twenty-six paretic or plegic dogs with IVDH with and without coexisting inflammatory disease were investigated in the acu

SUBMITTER: Wesolowski M 

PROVIDER: S-EPMC10362779 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature