Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study.

ABSTRACT:

Purpose

To investigate the association of genetically determined primary open-angle glaucoma (POAG), myopic refractive error (RE), type 2 diabetes (T2D), blood pressure (BP), body mass index (BMI), cigarette smoking, and alcohol consumption with the risk of age-related cataract.

Methods

To assess potential causal effects of clinical or behavioral factors on cataract risk, we conducted two-sample Mendelian randomization analyses. Genetic instruments, based on common genetic variants associated with risk factors at genome-wide significance (P < 5 × 10-8), were derived from published genome-wide association studies (GWAS). For age-related cataract, we used GWAS summary statistics from our previous GWAS conducted in the Genetic Epidemiology Research on Adult Health and Aging (GE

SUBMITTER: Jiang C 

PROVIDER: S-EPMC10362921 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature