The transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours.

ABSTRACT: Transposable elements (TEs) are genetic elements that have evolved as crucial regulators of human development and cancer, functioning as both genes and regulatory elements. When TEs become dysregulated in cancer cells, they can serve as alternate promoters to activate oncogenes, a process known as onco-exaptation. This study aimed to explore the expression and epigenetic regulation of onco-exaptation events in early human developmental tissues. We discovered co-expression of some TEs and oncogenes in human embryonic stem cells and first trimester and term placental tissues. Previous studies identified onco-exaptation events in various cancer types, including an AluJb SINE element-LIN28B interaction in lung cancer cells, and showed that the TE-derived LIN28B transcript is associated with po

SUBMITTER: Lynch-Sutherland CF 

PROVIDER: S-EPMC10363060 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature