Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers.

ABSTRACT: Aging manifests as progressive deteriorations in homeostasis, requiring systems-level perspectives to investigate the gradual molecular dysregulation of underlying biological processes. Here, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. These tightening patterns are similar across the interventions, particularly in processes such as fatty acid oxidation, immune response, and stress response. Differences in DIRAC patterns between

SUBMITTER: Watanabe K 

PROVIDER: S-EPMC10363145 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature