Dissecting shared genetic architecture between obesity and multiple sclerosis.

ABSTRACT:

Background

Observational studies have associated obesity with an increased risk of multiple sclerosis (MS). However, the role of genetic factors in their comorbidity remains largely unknown. Our study aimed to investigate the shared genetic architecture underlying obesity and MS.

Methods

By leveraging data from genome-wide association studies, we investigated the genetic correlation of body mass index (BMI) and MS by linkage disequilibrium score regression and genetic covariance analyser. The casualty was identified by bidirectional Mendelian randomisation. Linkage disequilibrium score regression in specifically expressed genes and multimarker analysis of GenoMic annotation was utilised to explore single-nucleotide polymorphism (SNP) enrichment at the tissue and cell-type le

SUBMITTER: Zeng R 

PROVIDER: S-EPMC10363440 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature