Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation.

ABSTRACT:

Purpose

Glioblastoma (GBM) is the most common type of adult brain tumor with extremely poor survival. Cystathionine-gamma lyase (CTH) is one of the main Hydrogen Sulfide (H₂S) producing enzymes and its expression contributes to tumorigenesis and angiogenesis but its role in glioblastoma development remains poorly understood.

Methods

and Principal Results: An established allogenic immunocompetent in vivo GBM model was used in C57BL/6J WT and CTH KO mice where the tumor volume and tumor microvessel density were blindly measured by stereological analysis. Tumor macrophage and stemness markers were measured by blinded immunohistochemistry. Mouse and human GBM cell lines were used for cell-based analyses. In human gliomas, the CTH expression was analyzed by bioinformat

SUBMITTER: Peleli M 

PROVIDER: S-EPMC10363444 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature