Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study.

ABSTRACT:

Background

Despite having the highest number of preterm births globally, no genomic study on preterm birth was previously published from India or other South-Asian countries.

Methods

We conducted a genome-wide association (GWA) study of spontaneous preterm birth (sPTB) on 6211 women from India. We used a novel resampling procedure to identify the associated single nucleotide polymorphisms (SNPs) followed by haplotype association analysis and imputation.

Findings

We found that 512 maternal SNPs were associated with sPTB (p < 2.51e-3), of which minor allele at 19 SNPs (after Bonferroni correction) had increased genotype relative risk. Haplotypes containing six of the 19 SNPs (rs13011430, rs8179838, rs2327290, rs4798499, rs7629800, and rs13180906) were associated

SUBMITTER: Bhattacharjee E 

PROVIDER: S-EPMC10363490 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature