Pressure support versus continuous positive airway pressure for predicting successful liberation from invasive ventilation in children: an open label, randomized non-inferiority trial.

ABSTRACT:

Background

Pressure support (PS) as a spontaneous breathing trial (SBT) was considered inferior to continuous positive airway pressure (CPAP) and T-piece because PS underestimated post-extubation work of breathing in physiologic studies. We aimed to compare PS and CPAP as SBT methods for assessing clinical outcomes in children.

Methods

This was an open label randomized non-inferiority trial conducted between December 2019 and August 2021 among children aged 1 month to 12 years deemed ready for weaning after at least 48 h of invasive ventilation in PICU. Children were randomized to undergo a 2-h SBT with PS of 8 cm H₂O in addition to PEEP 5-6 cm H₂O or CPAP (5-6 cm H₂O). The primary outcome was successful liberation from invasive ventilation f

SUBMITTER: Vishwa CR 

PROVIDER: S-EPMC10363498 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature