Pregnancy in Complement-Mediated Thrombotic Microangiopathy: Maternal and Neonatal Outcomes.

ABSTRACT:

Rationale & objective

Pregnancy, delivery, and neonatal outcomes in women with complement-mediated thrombotic microangiopathy (cTMA) have not been well described. A better understanding of these outcomes is necessary to provide women with competent pregnancy counseling.

Study design

Cohort study.

Setting and participants

Women with a history of cTMA and pregnancies enrolled into the Vienna thrombotic microangiopathy cohort.

Exposure

New onset or relapses of cTMA.

Outcomes

Pregnancy, delivery, and neonatal outcomes of pregnancies in women (a) before cTMA manifestation, (b) complicated by pregnancy-associated cTMA (P-cTMA), and (c) after first manifestation of cTMA or P-cTMA.

Analytical approach

Mixed models were used to adjust the comparison of pre

SUBMITTER: Haninger-Vacariu N 

PROVIDER: S-EPMC10363558 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature