Pseudotyped lentiviral vectors: Ready for translation into targeted cancer gene therapy?

ABSTRACT: Gene therapy holds great promise for curing cancer by editing the deleterious genes of tumor cells, but the lack of vector systems for efficient delivery of genetic material into specific tumor sites in vivo has limited its full therapeutic potential in cancer gene therapy. Over the past two decades, increasing studies have shown that lentiviral vectors (LVs) modified with different glycoproteins from a donating virus, a process referred to as pseudotyping, have altered tropism and display cell-type specificity in transduction, leading to selective tumor cell killing. This feature of LVs together with their ability to enable high efficient gene delivery in dividing and non-dividing mammalian cells in vivo make them to be attractive tools in future cancer gene therapy. This re

SUBMITTER: Deng L 

PROVIDER: S-EPMC10363566 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature