Ontology highlight
ABSTRACT:
SUBMITTER: Huo Y
PROVIDER: S-EPMC10363587 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Huo Yunfei Y Cao Ke K Kou Buxin B Chai Mengyin M Dou Shuangshuang S Chen Dexi D Shi Ying Y Liu Xiaoni X
Genes & diseases 20220905 5
Malignant tumor is still a major problem worldwide. During tumorigenesis or tumor development, tumor suppressor p53-binding protein 2 (TP53BP2), also known as apoptosis stimulating protein 2 of p53 (ASPP2), plays a critical role in p53 dependent and independent manner. Expression of TP53BP2 is highly correlated with the prognosis and survival rate of malignant tumor patients. TP53BP2 can interact with p53, NF-κB p65, Bcl-2, HCV core protein, PP1, YAP, CagA, RAS, PAR3, and other proteins to regul ...[more]