Titanium surfaces with biomimetic topography and copper incorporation to modulate behaviors of stem cells and oral bacteria.

ABSTRACT: Purpose: Insufficient osseointegration and implant-associated infection are major factors in the failure of Ti-based implants, thus spurring scientists to develop multifunctional coatings that are better suited for clinical requirements. Here, a new biomimetic micro/nanoscale topography coating combined with antibacterial copper was simultaneously designed for Ti-based implant surfaces by adopting a hybrid approach combining plasma electrolytic oxidation and hydrothermal treatment. Results: The biological interactions between this biofunctionalized material interface and stem cells promoted cellular adhesion and spreading during initial attachment and supported cellular proliferation for favorable biocompatibility. Bone marrow mesenchymal stem cells (BMMSCs) on the coating di

SUBMITTER: Li R 

PROVIDER: S-EPMC10363716 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature