Plasma urea cycle metabolite levels and the risk of moyamoya disease.

ABSTRACT:

Background and purpose

Urea cycle metabolites are expected to be the biomarkers for cerebrovascular diseases. However, the effects of circulating urea cycle metabolites on the risk of MMD and its subcategories remain unclear. The aim of this study was to prospectively investigate the association between plasma urea cycle metabolites and the risk of MMD and its subcategories.

Methods

We measured plasma urea cycle metabolite levels for 360 adult MMD patients and 89 matched healthy controls. Clinical and laboratory characteristics were obtained from the medical record. The study was conducted from July 2020 to December 2021.

Results

After multivariate adjustment, the risk of MMD increased with each increment in ornithine level (per natural log [ornithine] increment: OR,

SUBMITTER: Yu X 

PROVIDER: S-EPMC10363741 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature