Clinical and histopathological correlates of intestinal repair in preterm infants following surgical necrotizing enterocolitis.

ABSTRACT:

Objective

We sought to determine the clinical and histopathological factors linked with intestinal repair and its correlation with clinical outcomes in preterm infants following surgical necrotizing enterocolitis (NEC).

Methods

A retrospective study has compared clinical and histopathological characteristics between preterm infants with histopathological reparative changes versus non-reparative changes in resected intestinal tissue following surgical treatment of NEC. Reparative changes were defined as microscopic evidence of neovascularization, increased fibroblasts or myofibroblasts, and epithelial regeneration during histopathological examination of the most affected area of resected intestinal tissue.

Results

The infants with reparative changes (53/148) had signif

SUBMITTER: Garg PM 

PROVIDER: S-EPMC10363770 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature