Prognostic impact of LILRB4 expression on tumor-infiltrating cells in resected non-small cell lung cancer.

ABSTRACT:

Background

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4/ILT3) is an up-and-coming molecule that promotes immune evasion. We have previously reported that LILRB4 facilitates myeloid-derived suppressor cells (MDSCs)-mediated tumor metastasis in mice. This study aimed to investigate the impact of the LILRB4 expression levels on tumor-infiltrating cells on the prognosis of non-small cell lung cancer (NSCLC) patients.

Methods

We immunohistochemically evaluated the LILRB4 expression levels of completely resected 239 NSCLC specimens. Whether the blocking of LILRB4 on human PBMC-derived CD33⁺ MDSCs inhibited the migration ability of lung cancer cells was also examined using transwell migration assay.

Results

The LILRB4 ^high group,

SUBMITTER: Kumata S 

PROVIDER: S-EPMC10363795 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature