PD-1/PD-L1 based immunochemotherapy versus chemotherapy alone for advanced esophageal squamous cell carcinoma: A meta-analysis focus on PD-L1 expression level.

ABSTRACT:

Background

Immunochemotherapy has become a new treatment for advanced esophageal squamous cell carcinoma (ESCC).

Aims

We aimed to study the clinical efficacy and toxicity of immunochemotherapy based on PD-1/PD-L1 compared with chemotherapy alone in the treatment of advanced ESCC, focusing on analyzing the influence of PD-L1 expression level.

Methods and results

Five randomized controlled trials comparing PD-1/PD-L1 based immunochemotherapy with chemotherapy alone for advanced ESCC were included. We extracted efficacy data (objective response rate [ORR], disease control rate [DCR], overall survival [OS] rate, progression-free survival [PFS] rate) and safety data (treatment-related adverse events, treatment-related mortality) and performed meta-analyses. Compared with c

SUBMITTER: Jin Z 

PROVIDER: S-EPMC10363809 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature