Saccharomyces boulardii protects against murine experimental colitis by reshaping the gut microbiome and its metabolic profile.

ABSTRACT:

Introduction

Saccharomyces boulardii (S. boulardii) has shown clinical beneficial effect in inflammatory bowel diseases recently. However, the underlying mechanisms remain incompletely understood. The aim of present study was to tested whether S. boulardii targets gut microbiota to protect against the development of experimental colitis in mice.

Methods

Female C57BL/6 mice were gavaged with S. boulardii for 3 weeks before being challenged with dextran sulphate sodium to induce ulcerative colitis. Bodyweight, diarrhea severity, intestinal permeability, colonic histopathology, colonic inflammatory status, and epithelial cell death of mice were examined. The fecal microbiota and its metabolomic profiles were detected by 16S rDNA sequencing and UPLC-MS, resp

SUBMITTER: Gao H 

PROVIDER: S-EPMC10363984 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature