Dual wave of neutrophil recruitment determines the outcome of C. albicans infection.

ABSTRACT: Candida albicans is a ubiquitous fungus that can cause superficial and systemic infections in humans. Neutrophils play a crucial role in controlling C. albicans infections. When C. albicans enters the bloodstream, it tends to get trapped in capillary vessels. However, the behavior of neutrophils in combating capillary-residing fungi has not been fully characterized. In this study, we used transgenic mice and whole mount imaging to investigate the growth of C. albicans and its interaction with innate immune cells in different organs. We observed that C. albicans rapidly grows hyphae within hours of infection. Following intravenous infection, we observed two waves of neutrophil recruitment, both of which significantly contributed to the elimination of the f

SUBMITTER: Zhu W 

PROVIDER: S-EPMC10364056 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature