COVID-19 outcomes in patients with rheumatoid arthritis with biologic or targeted synthetic DMARDs.

ABSTRACT:

Objectives

We aimed to investigate the role of rheumatoid arthritis (RA) with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD) exposure in COVID-19 outcomes.

Methods

Our study retrieved data from the US Collaborative Network in TriNetX between 1 January 2018 and 31 December 2022. We investigated b/tsDMARD use for RA: interleukin 6 inhibitor (IL-6i), Janus-associated kinase inhibitors (JAKi) or tumour necrosis factor-alpha inhibitors (TNFi, reference group). The outcomes of COVID-19 were the incidence of infection and adverse outcomes (hospitalisation, critical care services, mechanical ventilation and mortality). The HR and 95% CI of the outcomes were calculated between propensity score-matched (PSM) patients with different b/tsDMARDs.

Resu

SUBMITTER: Tsai JJ 

PROVIDER: S-EPMC10364175 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature