Co-expression module analysis reveals high expression homogeneity for both coding and non-coding genes in sepsis.

ABSTRACT: Sepsis is a life-threatening condition characterized by a harmful host response to infection with organ dysfunction. Annually about 20 million people are dead owing to sepsis and its mortality rates is as high as 20%. However, no studies have been carried out to investigate sepsis from the system biology point of view, as previous research predominantly focused on individual genes without considering their interactions and associations. Here, we conducted a comprehensive exploration of genome-wide expression alterations in both mRNAs and long non-coding RNAs (lncRNAs) in sepsis, using six microarray datasets. Co-expression networks were conducted to identify mRNA and lncRNA modules, respectively. Comparing these sepsis modules with normal modules, we observed a homogeneous expression patte

SUBMITTER: Liu X 

PROVIDER: S-EPMC10364430 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature