Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment.

ABSTRACT:

Background

Macrophages take center stage in the tumor microenvironment, a niche composed of extracellular matrix and a heterogeneous group of cells, including immune ones. They can evolve during tumor progression and acquire Tumor-Associated Macrophage (TAMs) phenotype. The release of cytokines by tumor and stromal cells, influence the secretion of cytokines by TAMs, which can guarantee tumor progression and influence the response to therapy. Among all factors able to recruit and polarize macrophages, we focused our attention on Bcl-xL, a multifaceted member of the Bcl-2 family, whose expression is deregulated in melanoma. It acts not only as a canonical pro-survival and anti-apoptotic protein, but also as a promoter of tumor progression.

Methods

Human melanoma cells silenci

SUBMITTER: Luciano AM 

PROVIDER: S-EPMC10364435 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature