CD69+ resident memory T cells are associated with graft-versus-host disease in intestinal transplantation.

ABSTRACT: Graft-versus-host disease (GvHD) is a common, morbid complication after intestinal transplantation (ITx) with poorly understood pathophysiology. Resident memory T cells (T_RM ) are a recently described CD69+ memory T cell subset localizing to peripheral tissue. We observed that T effector memory cells (T_EM ) in the blood increase during GvHD and hypothesized that they derive from donor graft CD69+T_RM migrating into host blood and tissue. To probe this hypothesis, graft and blood lymphocytes from 10 ITx patients with overt GvHD and 34 without were longitudinally analyzed using flow cytometry. As hypothesized, CD4+ and CD8+CD69+T_RM were significantly increased in blood and grafts of GvHD patients, alongside higher cytokine and activation marker expr

SUBMITTER: Weiner J 

PROVIDER: S-EPMC10364625 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature