Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus.

ABSTRACT:

Introduction

Change in the composition of intestinal microbiota is associated with metabolic disorders such as gestational diabetes mellitus (GDM).

Methods

To understand how the microbiota impacts the development of gestational diabetes mellitus, we profiled the intestinal microbiome of 54 pregnant women, including 27 GDM subjects, by employing 16S rRNA gene sequencing. Additionally, we conducted targeted metabolomics assays to validate the identified pathways with overrepresented metabolites.

Results

We evaluated the patterns of changing abundances of operational taxonomic units (OTU) between GDM and the healthy counterparts over three timepoints. Based on the significant OTUs, we inferred 132 significantly altered metabolic pathways in GDM. And identified two overre

SUBMITTER: Lyu X 

PROVIDER: S-EPMC10364628 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature