Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis.

ABSTRACT: Formyl peptide receptor-1 (FPR1) is a pattern recognition receptor that is mostly expressed by myeloid cells. In patients with colorectal cancer (CRC), a loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associated with reduced responses to chemotherapy or chemoradiotherapy. Moreover, rs867228 is associated with accelerated esophageal and colorectal carcinogenesis. Here, we show that dendritic cells from Fpr1^-/- mice exhibit reduced migration in response to chemotherapy-treated CRC cells. Moreover, Fpr1^-/- mice are particularly susceptible to chronic ulcerative colitis and colorectal oncogenesis induced by the mutagen azoxymethane followed by oral dextran sodium sulfate, a detergent that induces colitis. These experiments were

SUBMITTER: Le Naour J 

PROVIDER: S-EPMC10364666 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature