Effect of prucalopride to improve time to gut function recovery following elective colorectal surgery: randomized clinical trial.

ABSTRACT:

Background

Delayed return to gut function and prolonged postoperative ileus (PPOI) delay recovery after colorectal surgery. Prucalopride is a selective serotonin-4-receptor agonist that may improve gut motility.

Methods

This was a multicentre, double-blind, parallel, placebo-controlled randomized trial of 2 mg prucalopride versus placebo in patients undergoing elective colorectal resection. Patients with inflammatory bowel disease and planned ileostomy formation were excluded, but colostomy formation was allowed. The study medication was given 2 h before surgery and daily for up to 6 days after operation. The aim was to determine whether prucalopride improved return of gut function and reduced the incidence of PPOI. The primary endpoint was time to passage of stool and toler

SUBMITTER: Milne T 

PROVIDER: S-EPMC10364744 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature