Severity of oEsophageal Anastomotic Leak in patients after oesophagectomy: the SEAL score.

ABSTRACT:

Background

Anastomotic leak (AL) is a common but severe complication after oesophagectomy. It is unknown how to determine the severity of AL objectively at diagnosis. Determining leak severity may guide treatment decisions and improve future research. This study aimed to identify leak-related prognostic factors for mortality, and to develop a Severity of oEsophageal Anastomotic Leak (SEAL) score.

Methods

This international, retrospective cohort study in 71 centres worldwide included patients with AL after oesophagectomy between 2011 and 2019. The primary endpoint was 90-day mortality. Leak-related prognostic factors were identified after adjusting for confounders and were included in multivariable logistic regression to develop the SEAL score. Four classes of leak severity (

SUBMITTER: Ubels S 

PROVIDER: S-EPMC10364775 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature