Fenton-like Chemistry by a Copper(I) Complex and H₂O₂ Relevant to Enzyme Peroxygenase C-H Hydroxylation.

ABSTRACT: Lytic polysaccharide monooxygenases have received significant attention as catalytic convertors of biomass to biofuel. Recent studies suggest that its peroxygenase activity (i.e., using H₂O₂ as an oxidant) is more important than its monooxygenase functionality. Here, we describe new insights into peroxygenase activity, with a copper(I) complex reacting with H₂O₂ leading to site-specific ligand-substrate C-H hydroxylation. [Cu^I(TMG₃tren)]⁺ (1) (TMG₃tren = 1,1,1-Tris{2-[N²-(1,1,3,3-tetramethylguanidino)]ethyl}amine) and a dry source of hydrogen peroxide, (o-Tol₃P═O·H₂O₂)₂ react in the stoichiometry, [Cu^I(TMG₃

SUBMITTER: Kim B 

PROVIDER: S-EPMC10364799 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature