Uncovering Footprints of Natural Selection Through Spectral Analysis of Genomic Summary Statistics.

ABSTRACT: Natural selection leaves a spatial pattern along the genome, with a haplotype distribution distortion near the selected locus that fades with distance. Evaluating the spatial signal of a population-genetic summary statistic across the genome allows for patterns of natural selection to be distinguished from neutrality. Considering the genomic spatial distribution of multiple summary statistics is expected to aid in uncovering subtle signatures of selection. In recent years, numerous methods have been devised that consider genomic spatial distributions across summary statistics, utilizing both classical machine learning and deep learning architectures. However, better predictions may be attainable by improving the way in which features are extracted from these summary statistics. We apply wa

SUBMITTER: Arnab SP 

PROVIDER: S-EPMC10365025 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature