Effect of pituitary-dependent hypercortisolism on the survival of dogs treated with radiotherapy for pituitary macroadenomas.

ABSTRACT:

Background

Radiotherapy (RT) is an effective treatment for dogs presented with neurologic signs caused by pituitary tumors. However, its impact on the outcome of concurrent pituitary-dependent hypercortisolism (PDH) is controversial.

Objectives

Determine whether dogs with PDH have longer survival after pituitary RT compared with dogs with nonhormonally active pituitary masses and to evaluate whether clinical, imaging, and RT variables affect survival.

Animals

Ninety-four dogs divided into 2 groups: PDH and non-PDH, based on the presence of hypercortisolism. Forty-seven dogs were allocated to the PDH group and 47 to the non-PDH group.

Methods

Retrospective cohort study in which clinical records of dogs undergoing RT for pituitary macroadenomas between 2008 and 2

SUBMITTER: Rapastella S 

PROVIDER: S-EPMC10365051 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature