Effect of a specially formulated diet on progression of heart enlargement in dogs with subclinical degenerative mitral valve disease.

ABSTRACT:

Background

Previous studies in dogs with degenerative mitral valve disease (DMVD) have identified altered myocardial energy metabolism and oxidation, which might contribute to cardiac hypertrophy. Diets rich in medium chain fatty acids and antioxidants are a potential means of treatment. A previous clinical study found significantly smaller left atrial diameter (LAD) and left atrium-to-aorta diameter ratio (LA : Ao) in dogs with subclinical DMVD fed a specially formulated diet vs control diet for 6 months.

Hypothesis/objectives

A specially formulated diet will slow or arrest left heart enlargement in dogs with subclinical DMVD over 365 days.

Animals

One hundred twenty-seven dogs with unmedicated subclinical DMVD; 101 dogs in the per protocol cohort.

Methods

Ran

SUBMITTER: Oyama MA 

PROVIDER: S-EPMC10365052 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature