Dataset Information

Red blood cell distribution width to platelet ratio in neonatal foals with sepsis.

ABSTRACT:

Background

Rapid and accurate markers to aid diagnosis of sepsis are needed in neonatal foals. The CBC variable red blood cell distribution width (RDW) to platelet ratio (RPR) is associated with inflammatory response and linked to poor outcomes of sepsis in human patients.

Hypothesis

Explore the correlation of RPR with sepsis in neonatal foals and evaluate RPR predictive and prognostic value.

Animals

Three hundred seventeen hospitalized neonatal foals ≤7 days of age that had a CBC and physical exam performed at admission between 2012 and 2021.

Methods

Retrospective case-control study. Clinical records were used to calculate sepsis scores and define groups. Red blood cell distribution width to platelet ratio was calculated and compared between groups (septic vs nonseptic) based on Kruskal-Wallis and Wilcoxon signed-rank tests. A multivariate logistic regression model to predict sepsis was created. The cutoff for RPR was obtained based on the maximal Youden Index. The Kaplan-Meier method and the log-rank test were used to estimate survival curves and compare survival rates based on RPR.

Results

Red blood cell distribution width to platelet ratio was significantly higher in septic foals (Median = 0.099, confidence interval [CI] [0.093; 0.108]) than in sick nonseptic (0.085, CI [0.083; 0.089]) and healthy foals (0.081, CI [0.077; 0.086]; P < .0001). Red blood cell distribution width to platelet ratio was able to predict sepsis with high accuracy (AUC = 82.1%). The optimal RPR cutoff for sepsis was 0.09.

Conclusions and clinical importance

Red blood cell distribution width to platelet ratio calculation is practical, inexpensive, and based on CBC-derived data. Calculation of RPR along with CBC can aid in the diagnosis of sepsis and estimation of outcome.

SUBMITTER: Scalco R

PROVIDER: S-EPMC10365058 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Red blood cell distribution width to platelet ratio in neonatal foals with sepsis.

Scalco Rebeca R de Oliveira Gabriela Novo GN da Rosa Curcio Bruna B Wooten McCaide M Magdesian K Gary KG Hidai Stephanie Takako ST Pandit Pranav P Aleman Monica M

Journal of veterinary internal medicine 20230612 4

<h4>Background</h4>Rapid and accurate markers to aid diagnosis of sepsis are needed in neonatal foals. The CBC variable red blood cell distribution width (RDW) to platelet ratio (RPR) is associated with inflammatory response and linked to poor outcomes of sepsis in human patients.<h4>Hypothesis</h4>Explore the correlation of RPR with sepsis in neonatal foals and evaluate RPR predictive and prognostic value.<h4>Animals</h4>Three hundred seventeen hospitalized neonatal foals ≤7 days of age that ha ...[more]

PMID: 37306395

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Dataset Information

Red blood cell distribution width to platelet ratio in neonatal foals with sepsis.

Background

Hypothesis

Animals

Methods

Results

Conclusions and clinical importance

Publications

Red blood cell distribution width to platelet ratio in neonatal foals with sepsis.

Similar Datasets

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