Integrating Transcriptomics, Genomics, and Imaging in Alzheimer's Disease: A Federated Model.

ABSTRACT: Alzheimer's disease (AD) affects more than 1 in 9 people age 65 and older and becomes an urgent public health concern as the global population ages. In clinical practice, structural magnetic resonance imaging (sMRI) is the most accessible and widely used diagnostic imaging modality. Additionally, genome-wide association studies (GWAS) and transcriptomics-the study of gene expression-also play an important role in understanding AD etiology and progression. Sophisticated imaging genetics systems have been developed to discover genetic factors that consistently affect brain function and structure. However, most studies to date focused on the relationships between brain sMRI and GWAS or brain sMRI and transcriptomics. To our knowledge, few methods have been developed to discover and infer mult

SUBMITTER: Wu J 

PROVIDER: S-EPMC10365097 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature