Variability and reproducibility of multi-echo T₂ relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions.

ABSTRACT: Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acquired in a healthy population. This study focuses on multi-echo T₂ relaxometry, a qMRI technique that probes the complex tissue microstructure by differentiating compartment-specific T₂ relaxation times. However, estimation methods are still limited by their sensitivity to the underlying noise. Moreover, estimating the model's parameters is challenging because the resulting inverse problem is ill-posed, requiring advanced numerical regularization techniques. As a result, the estimates from distinct regul

SUBMITTER: Fischi-Gomez E 

PROVIDER: S-EPMC10365099 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature