Role of phagocyte extracellular traps during Mycobacterium tuberculosis infections and tuberculosis disease processes.

ABSTRACT: Mycobacterium tuberculosis (M.tb) infections remain one of the most significant causes of mortality worldwide. The current situation shows an emergence of new antibiotic-resistant strains making it difficult to control the tuberculosis (TB) disease. A large part of its success as a pathogen is due to its ability to persist for years or even decades without causing evident clinical manifestations. M.tb is highly successful in evading the host-defense by manipulating host-signalling pathways. Although macrophages are generally viewed as the key cell type involved in harboring M.tb, growing evidence shows that neutrophils also play a fundamental role. Both cells are known to act in multiple ways when encountering an invading pathogen, including phagocytosis, releas

SUBMITTER: Garcia-Bengoa M 

PROVIDER: S-EPMC10365110 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature