Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD.

ABSTRACT:

Purpose

Early and intermediate non-neovascular AMD (NN-AMD) has the potential to progress to either advanced NN-AMD with geographic atrophy, or to neovascular AMD (N-AMD) with CNV. This exploratory study performed an unbiased analysis of aqueous humor transcriptome in patients with early or intermediate NN-AMD vs. treatment-naïve N-AMD to determine the feasibility of using this method in future studies investigating pathways and triggers for conversion from one form to another.

Methods

Aqueous humor samples were obtained from 20 patients with early or intermediate NN-AMD and 20 patients with untreated N-AMD, graded on clinical examination and optical coherence tomography. Transcriptome profiles were generated using next-generation sequencing methods optimized for ocular samp

SUBMITTER: Kaidonis G 

PROVIDER: S-EPMC10365141 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature