In silico study of phytochemicals contained in Brucea javanica in inhibiting the InhA enzyme as antituberculosis.

ABSTRACT:

Background

Currently Mycobacterium tuberculosis is found to be resistant to the treatment of tuberculosis with rifampin and isoniazid (INH) and often stated as multi-drug resistance (MDR). Knowledge and determination of biological properties of plant extracts is a source of drug candidates in various health fields. Therefore, natural products are important in the discovery of new drugs, especially in disease therapy, particularly for tropical diseases, tuberculosis. Brucea javanica, known as Buah Makasar, is found in many Asian countries including Indonesia. This plant fruit has a very bitter taste so it cannot be directly consumed and is often used as a traditional medicine to prevent some diseases, especially malaria. There has been no research on the effecti

SUBMITTER: Sulistyowaty MI 

PROVIDER: S-EPMC10365667 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature