Whole slide imaging (WSI) scanner differences influence optical and computed properties of digitized prostate cancer histology.

ABSTRACT:

Purpose

Digital pathology is becoming an increasingly popular area of advancement in both research and clinically. Pathologists are now able to manage and interpret slides digitally, as well as collaborate with external pathologists with digital copies of slides. Differences in slide scanners include variation in resolution, image contrast, and optical properties, which may influence downstream image processing. This study tested the hypothesis that varying slide scanners would result in differences in computed pathomic features on prostate cancer whole mount slides.

Design

This study collected 192 unique tissue slides from 30 patients following prostatectomy. Tissue samples were paraffin-embedded, stained for hematoxylin and eosin (H&E), and digitized using 3 different scan

SUBMITTER: Duenweg SR 

PROVIDER: S-EPMC10365953 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature