Microevolutionary processes analysis in the Lithuanian genome.

ABSTRACT: Differences in the relative fitness of genomic variants are foundational, without these, neither natural selection nor adaption can exist. This research analyzed two microevolutionary forces, mutations, and positive selection, using whole genome sequencing data from Lithuanians across three generations: newborns (generation I), their parents (generation II), 60 years old Lithuanians, and the root ancestors (generation III). The main objective was to determine the frequency of mutations under selection in modern humans and how allele frequencies change across generations. Our results show that going through all the landscapes of the relative fitness on each chromosome, the general relative fitness background pattern remains the same in analysed generations. However, the tendency of relative

SUBMITTER: Pranckeniene L 

PROVIDER: S-EPMC10366082 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature