A performance evaluation of drug response prediction models for individual drugs.

ABSTRACT: Drug response prediction is important to establish personalized medicine for cancer therapy. Model construction for predicting drug response (i.e., cell viability half-maximal inhibitory concentration [IC₅₀]) of an individual drug by inputting pharmacogenomics in disease models remains critical. Machine learning (ML) has been predominantly applied for prediction, despite the advent of deep learning (DL). Moreover, whether DL or traditional ML models are superior for predicting cell viability IC_50s has to be established. Herein, we constructed ML and DL drug response prediction models for 24 individual drugs and compared the performance of the models by employing gene expression and mutation profiles of cancer cell lines as input. We observed no significant difference

SUBMITTER: Park A 

PROVIDER: S-EPMC10366128 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature