Effects of oxidative stress on hepatic encephalopathy pathogenesis in mice.

ABSTRACT: Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but the mechanism remains unclear. GABAergic neurons in substantia nigra pars reticulata (SNr) contribute to the motor deficit of HE. The present study aims to investigate the effects of oxidative stress on HE in male mice. The results validate the existence of oxidative stress in both liver and SNr across two murine models of HE induced by thioacetamide (TAA) and bile duct ligation (BDL). Systemic mitochondria-targeted antioxidative drug mitoquinone (Mito-Q) rescues mitochondrial dysfunction and oxidative injury in SNr, so as to restore the locomotor impairment in TAA and BDL mice. Furthermore, the GAD2-expressing SNr population (SNr^GAD2) is activated by HE. Both overexpression of mitochon

SUBMITTER: Bai Y 

PROVIDER: S-EPMC10366183 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature