Influence of nanoparticle encapsulation and encoding on the surface chemistry of polymer carrier beads.

ABSTRACT: Surface-functionalized polymer beads encoded with molecular luminophores and nanocrystalline emitters such as semiconductor nanocrystals, often referred to as quantum dots (QDs), or magnetic nanoparticles are broadly used in the life sciences as reporters and carrier beads. Many of these applications require a profound knowledge of the chemical nature and total number of their surface functional groups (FGs), that control bead charge, colloidal stability, hydrophobicity, and the interaction with the environment and biological systems. For bioanalytical applications, also the number of groups accessible for the subsequent functionalization with, e.g., biomolecules or targeting ligands is relevant. In this study, we explore the influence of QD encoding on the amount of carboxylic acid (COOH)

SUBMITTER: Scholtz L 

PROVIDER: S-EPMC10366211 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature