Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.

ABSTRACT:

Objectives

Small-diameter afferent axons carry various sensory signals that are critical for vital physiological conditions but sometimes contribute to pathologies. Infrared (IR) neural inhibition (INI) can induce selective heat block of small-diameter axons, which holds potential for translational applications such as pain management. Previous research suggested that IR-heating-induced acceleration of voltage-gated potassium channel kinetics is the mechanism for INI. Therefore, we hypothesized that other heating methods, such as resistive heating (RH) in a cuff, could reproduce the selective inhibition observed in INI.

Materials and methods

We conducted ex vivo nerve-heating experiments on pleural-abdominal connective nerves of Aplysia californica using both IR and RH. We f

SUBMITTER: Zhuo J 

PROVIDER: S-EPMC10366334 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature