The differential response to neuronal hyperexcitation and neuroinflammation of the hippocampal neurogenic niche.

ABSTRACT: Hippocampal neurogenesis is a tightly regulated process in which neural stem cells (NSCs) get activated, enter in the cell cycle and give rise to neurons after a multistep process. Quiescent and activated NSCs, neural precursors, immature and mature neurons and newborn astrocytes coexist in the neurogenic niche in a strictly controlled environment which maintains the correct functioning of neurogenesis. NSCs are the first step in the neurogenic process and are a finite and, mostly, non-renewable resource, therefore any alteration of the intrinsic properties of NSCs will impact the total neurogenic output. Neuronal hyperexcitation is a strong activator of NSCs prompting them to divide and therefore increasing neurogenesis. However, neuronal hyperactivity is not an isolated process but often

SUBMITTER: Ruiz-Clavijo L 

PROVIDER: S-EPMC10366379 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature