Low and high serum IgG associates with respiratory infections in a young and working age population.

ABSTRACT:

Background

We investigated health consequences and genetic properties associated with serum IgG concentration in a young and working age general population.

Methods

Northern Finland Birth Cohort 1966 (NFBC1966, n = 12,231) health data have been collected from birth to 52 years of age. Relationships between life-long health events, medications, chronic conditions, lifestyle, and serum IgG concentration measured at age 46 years (n = 5430) were analysed. Regulatory mechanisms of serum IgG concentration were considered.

Findings

Smoking and genetic variation (FCGR2B and TNFRSF13B) were the most important determinants of serum IgG concentration. Laboratory findings suggestive of common variable immunodeficiency (CVID) were 10-fold higher compared to previous reports (73.7

SUBMITTER: Holma P 

PROVIDER: S-EPMC10366395 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature