Multifunctional silk vinyl sulfone-based hydrogel scaffolds for dynamic material-cell interactions.

ABSTRACT: Biochemical and mechanical interactions between cells and the surrounding extracellular matrix influence cell behavior and fate. Mimicking these features in vitro has prompted the design and development of biomaterials, with continuing efforts to improve tailorable systems that also incorporate dynamic chemical functionalities. The majority of these chemistries have been incorporated into synthetic biomaterials, here we focus on modifications of silk protein with dynamic features achieved via enzymatic, "click", and photo-chemistries. The one-pot synthesis of vinyl sulfone modified silk (SilkVS) can be tuned to manipulate the degree of functionalization. The resultant modified protein-based material undergoes three different gelation mechanisms, enzymatic, "click", and light-induced, to ge

SUBMITTER: Falcucci T 

PROVIDER: S-EPMC10366540 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature