Alteration and clinical potential in gut microbiota in patients with cerebral small vessel disease.

ABSTRACT:

Background

Cerebral small vessel disease (CSVD) is a cluster of microvascular disorders with unclear pathological mechanisms. The microbiota-gut-brain axis is an essential regulatory mechanism between gut microbes and their host. Therefore, the compositional and functional gut microbiota alterations lead to cerebrovascular disease pathogenesis. The current study aims to determine the alteration and clinical value of the gut microbiota in CSVD patients.

Methods

Sixty-four CSVD patients and 18 matched healthy controls (HCs) were included in our study. All the participants underwent neuropsychological tests, and the multi-modal magnetic resonance imaging depicted the changes in brain structure and function. Plasma samples were collected, and the fecal samples were analyzed with

SUBMITTER: Shi Y 

PROVIDER: S-EPMC10366612 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature