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Fluorinated hydrogel nanoparticles with regulable fluorine contents and T₂ relaxation times as ¹⁹F MRI contrast agents.

ABSTRACT: Medical imaging contrast agents that are able to provide detailed biological information have attracted increasing attention. Among the new emerging imaging contrast agents, ¹⁹F magnetic resonance imaging contrast agents (¹⁹F MRI CAs) are extremely promising for their weak background disturbing signal from the body. However, to prepare ¹⁹F MRI CAs with a long T₂ relaxation time and excellent biocompatibility in a simple and highly effective strategy is still a challenge. Herein, we report a new type of ¹⁹F MRI hydrogel nanocontrast agents (¹⁹F MRI HNCAs) synthesized by a surfactant-free emulsion polymerization with commercial fluorinated monomers. The T₂ relaxation time of ¹⁹F MRI HNCA-1 was found to be 25-40 ms, guaranteeing its good imaging ability in vitro. In addition, according to an investigation into the relationship between the fluorine content and ¹⁹F MRI signal intensity, the ¹⁹F MRI signal intensity was not only determined by the fluorine content in ¹⁹F MRI HNCAs but also by the hydration microenvironment around the fluorine atoms. Moreover, ¹⁹F MRI HNCAs demonstrated excellent biocompatibility and imaging capability inside cells. The primary exploration demonstrated that ¹⁹F MRI HNCAs as a new type of ¹⁹F MRI contrast agent hold potential for imaging lesion sites and tracking cells in vivo by ¹⁹F MRI technology.

SUBMITTER: Duan Z

PROVIDER: S-EPMC10366653 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Fluorinated hydrogel nanoparticles with regulable fluorine contents and T2 relaxation times as 19F MRI contrast agents.

Duan Ziwei Z Liu Changjiang C Tang Junjie J Zhang Ruling R Peng Danfeng D Lu Ruitao R Cao Zong Z Wu Dalin D

RSC advances 20230725 32

Medical imaging contrast agents that are able to provide detailed biological information have attracted increasing attention. Among the new emerging imaging contrast agents, 19F magnetic resonance imaging contrast agents (19F MRI CAs) are extremely promising for their weak background disturbing signal from the body. However, to prepare 19F MRI CAs with a long T2 relaxation time and excellent biocompatibility in a simple and highly effective stra ...[more]

PMID: 37497094

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Project description:BackgroundExercise therapy is considered preferential treatment for patellar tendinopathy (PT). However, there is conflicting evidence for structural patellar tendon adaptation in response to exercise therapy and its association with symptoms is weak.PurposeTo assess the association between 1) T2 * relaxation times and symptom severity; 2) baseline T2 * and clinical outcome; and 3) longitudinal T2 * changes and clinical outcome in athletes with PT performing exercise therapy.Study typeRandomized controlled clinical trial.SubjectsSeventy-six athletes (18-35 years) with clinically diagnosed and ultrasound-confirmed PT.Field strength/sequence3D gradient echo sequence (3.0 T).AssessmentPatients were enrolled in a randomized trial of progressive tendon-loading exercises (PTLE) versus eccentric exercise therapy (EET). Symptoms were assessed using the Victorian Institute of Sports Assessment (VISA-P) questionnaire. 3D-Ultrashort echo time (UTE)-MRI was acquired at baseline, 12 and 24 weeks. Voxel-wise T2 * relaxation times were quantified using mono-exponential and bi-exponential models. T2 * analysis was performed in three patellar tendon tissue compartments representing: aligned collagen, degenerative tissue, and interface.Statistical testsAdjusted general linear, mixed-linear models, and generalized estimating equations.ResultsWe included 76 patients with PT (58 men, mean age 24 ± 4 years); 38 in the PTLE-group and 38 in the EET-group, of which 57 subjects remained eligible for analysis. T2 * relaxation times were significantly associated with VISA-P in degenerative and interface tissues of the patellar tendon. No association was found between baseline T2 * and VISA-P after 24 weeks (P > 0.29). The estimated mean T2 * in degenerative tissue decreased from 14 msec (95%CI: 12-16) at baseline to 13 msec (95%CI: 11-15) at 12 weeks and to 13 msec (95%CI: 10-15) at 24 weeks. The significant decrease in T2 * from baseline to 24 weeks was associated with improved clinical outcome.Data conclusionTissue-specific T2 * relaxation times, identified with 3D-UTE-MRI, decreased significantly in athletes with patellar tendinopathy performing exercise therapy and this decrease was associated with improved clinical outcome.Evidence level1 TECHNICAL EFFICACY: Stage 4.

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Fluorinated hydrogel nanoparticles with regulable fluorine contents and T₂ relaxation times as ¹⁹F MRI contrast agents.

Publications

Fluorinated hydrogel nanoparticles with regulable fluorine contents and <i>T</i><sub>2</sub> relaxation times as <sup>19</sup>F MRI contrast agents.

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