Fluorinated hydrogel nanoparticles with regulable fluorine contents and T₂ relaxation times as ¹⁹F MRI contrast agents.

ABSTRACT: Medical imaging contrast agents that are able to provide detailed biological information have attracted increasing attention. Among the new emerging imaging contrast agents, ¹⁹F magnetic resonance imaging contrast agents (¹⁹F MRI CAs) are extremely promising for their weak background disturbing signal from the body. However, to prepare ¹⁹F MRI CAs with a long T₂ relaxation time and excellent biocompatibility in a simple and highly effective strategy is still a challenge. Herein, we report a new type of ¹⁹F MRI hydrogel nanocontrast agents (¹⁹F MRI HNCAs) synthesized by a surfactant-free emulsion polymerization with commercial fluorinated monomers. The T₂ relaxation time of ¹⁹F MRI HNCA-1 w

SUBMITTER: Duan Z 

PROVIDER: S-EPMC10366653 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature