The role of CD8+ T cells in endometriosis: a systematic review.

ABSTRACT:

Background

Endometriosis is a chronic disease affecting 6-10% of women of reproductive age. It is an important cause of infertility and chronic pelvic pain with poorly understood aetiology. CD8+ T (CD8 T) cells were shown to be linked to infertility and chronic pain and play a significant role in lesion clearance in other pathologies, yet their function in endometriosis is unknown. We systematically evaluated the literature on the CD8 T in peripheral blood and endometriosis-associated tissues to determine the current understanding of their pathophysiological and clinical relevance in the disease and associated conditions (e.g. infertility and pelvic pain).

Methods

Four databases were searched (MEDLINE, EMBASE, Web of Science, CINAHL), from database inception until September

SUBMITTER: Kisovar A 

PROVIDER: S-EPMC10366819 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature