DoxoDB: A Database for the Expression Analysis of Doxorubicin-Induced lncRNA Genes.

ABSTRACT: Cancer and cardiovascular disease are the leading causes of death worldwide. Recent evidence suggests that these two life-threatening diseases share several features in disease progression, such as angiogenesis, fibrosis, and immune responses. This has led to the emergence of a new field called cardio-oncology. Doxorubicin is a chemotherapy drug widely used to treat cancer, such as bladder and breast cancer. However, this drug causes serious side effects, including acute ventricular dysfunction, cardiomyopathy, and heart failure. Based on this evidence, we hypothesize that comparing the expression profiles of cells and tissues treated with doxorubicin may yield new insights into the adverse effects of the drug on cellular activities. To test this hypothesis, we analyzed published RNA seque

SUBMITTER: Distefano R 

PROVIDER: S-EPMC10366827 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature